Hybridoma Producing Monoclonal Antibodies To Murine Icos

Abstract

Investigators at University of California have made a panel of hybridomas producing monoclonal antibodies to the ectodomain of murine ICOS from Syrian hamsters with Chinese hamster ovary cells (CHO) transfected with the murine ICOS gene. Two hybridoma lines were identified; 27A12 (Igm) and 151-9 (IgG).

Ref: Dong, C, Juedes, AE, Temann, UA, Shresta, S, Allison, JP, Ruddle, NH, and Flavell, RA. 2001. ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature. 409:97-101